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Title   단독 방사선치료를 받은 병기 IIB 자궁경부 편평상피암에서 Apoptosis 와 P53 단백질 발현의 임상적 의의 ( Clinical Significance of Apoptosis and p53 Protein Expression in Stage IIB Squamous Cell Carcinoma of the Cervix Treated with Radiotherapy Alone )
Publicationinfo   2000 Jan; 032(03): 638-647.
Key_word   Cervix neoplasm , Radiotherapy , Apoptosis , p53 protein
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Abstract   Purpose: The purpose was to investigate the spontaneous apoptotic index (SAI) and p53 protein expression and to identify the role of SAI and p53 protein positivity. Materials and Methods: Forty six patients with squamous cell carcinoma of the cervix, FIGO stage IIB, treated with curative radiotherapy alone between 1990 and 1993 were included in this study. Definitive radiotherapy including external beam and high-dose-rate brachytherapy was given. Pretreatment paraffin-embedded biopsy specimens of those patients were scored for apoptosis and p53 protein expression using mouse monoclonal antibody (DO-7) by immuno-staining. Clinicopathologic characteristics were also studied in relation to SAI and p53 protein expression, and as prognostic factors for clinical outcome. Results: SAI and p53 were not related to any clinical characteristics. The range of the SAI was 0.2~4.7% (median 1.1%, mean 1.5%). The rate of p53 protein expression was 65.2% (30/46). Patients whose tumors had high SAI and low p53 protein positivity had better treatment outcome than those with lower SAI. There was also a significant correlation between the SAI and p53 protein expression, Conclusion: The pretreatment SAI and p53 oncoprotein expression are clinically useful in predicting the clinical outcome of FIGO stage IIB squamous cell carcinoma of the uterine cervix patients treated with definitive radiotherapy.
저 자   정은지(Eun Ji Chung),김귀언(Gwi Eon Kim),성진실(Jin Sil Seong),양우의(Woo Ick Yang),김영태(Young Tae Kim),서창옥(Chang Ok Suh)